I have run Fedora for over a decade and switched to Bazzite a couple years ago for my desktop (Fedora still on my server).
In short, yes, but I wouldn’t recommend it. You can learn what you need to directly on Bazzite. If you’re looking for help, Bazzite is most similar to Fedora Silverblue (not regular Fedora) under the covers. The differences between regular Fedora and Bazzite are substantial enough that you’ll run into some things you’d need to research twice, once for Fedora then again for Bazzite. Keep it simple and just use Bazzite.
If you want or need a distribution with a different focus, you should look at the other Universal Blue (ublue) options. Bazzite is built on ublue for gamers, but uBlue also builds for other use cases. Aurora for general desktop, Bluefin for workstation, and uCore for servers.
Oh, then yeah, Fedora is closest. But I’d recommend at least trying an immutable distro --, immutable distributions have been excellent to me (and I dig in my systems a lot), so much so that I’m considering moving my server over, and we already use them on our Linux fleet at work.