NebiOS is an Ubuntu-based desktop Linux distribution with a custom Wayland compositor called NebiDE (based on Wayfire). It features various user interface enhancements, an initial setup module called OOBE, the NebiOS App Runtime (napp-runtime) portable application format with bubblewrap containerization, improved gaming performance with Steam Proton integration, a kernel switcher for easy multi-kernel installation, and the Wine compatibility layer for running some Windows applications. NebiOS is intended as a general-purpose operating system for daily computing tasks, including creative work and gaming.

https://distrowatch.com/table-mobile.php?distribution=nebios

What’s the difference between doing this and just using pipx?